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Neftali Eduardo Antonio-Villa
I am currently carrying out my primary research activities as an early career member in the Department of Public Health at the Faculty of Medicine of the National Autonomous University of Mexico. My primary line of investigation focused on studying the impact of the social determinants of health and the relationship with cardiometabolic diseases of the population living in Latin America.
Education
Ph.D.
Mexico City, Mexico
Faculty Of Medicine - Universidad Nacional Autónoma De México (UNAM)
2023 - 2020
- Project: Evaluation of the impact of social inequalities on the prevalence of risk factors and cardiovascular mortality rates in the population of Latin America and the Caribbean.
- Mentorship: Dr. Omar Yaxmehen Bello-Chavolla
M.D.
Mexico City, Mexico
Faculty Of Medicine - Universidad Nacional Autónoma De México (UNAM)
2020 - 2015
Research Experience
Undergraduate Researcher
Metabolic Disease Research Unit
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2019 - 2018
- Research internship under the tutelage of Dr. Carlos Alberto Aguilar-Salinas
- Projects: Development and validation of a visceral adipose tissue estimator using non-linear regression model approach for prediction of T2D and arterial hypertension.
- Products: 10 published articles, two book chapters.
Undergraduate Researcher
Nuclear Cardiology Department
Instituto Nacional De Cardiologia Ignacio Chavez
2018 - 2017
- Research internship under the tutelage of Dr. Nilda Espinola-Zavaleta and Erick Alexanderson-Rosas at the National Institute of Cardiology Ignacio Chavez in Mexico City.
- Project: Assessment of comorbidities and clinical risk factors within subject who are assessed by SPECT-CT.
- Products: 4 published articles.
Undergraduate Researcher
Public Health Deparment
Faculty Of Medicine - Universidad Nacional Autónoma De México (UNAM)
2016 - 2016
- Research internship under the tutelage of Dr. Laura Leticia Tirado Gomez at the National Autonomous University of Mexico.
- Project: Prevalence and incidence changes during the last two decades of lung cancer mortality in Mexico.
- Products: Basic training in public health policies and estimators. Acknowledgment in a published article.
Awards, innovations, and congress presentations
Areas of Expertise: Datasets management, Statistics of central tendency and variability, Probability distributions, Simple linear regression, Multiple linear regression, Experimental design, Fixed and random effects models, Analysis of experiments, Analysis of cross-sectional studies and Cases and Controls, Mediation analysis, Unsupervised modeling with regression methods, Survival analysis and Cox regression, Competitive risk models, Calibration of predictive models
Featured Abstract Award
ENDO2021
Atlanta, Georgia
2021
- Trends in Diabetes Subgroups and Their Risk for All-Cause, Cardiovascular Disease and Diabetes-Specific Mortality in the US: A Data-Driven Reproducible Machine Learning Approach
- https://www.endocrine.org/awards/the-endocrine-society-outstanding-abstract-awards
Presidential Poster Award
ENDO2019
New Orleans, Louisiana.
2019
- Cathegory Adipose Tissue, Appetite, and Obesity for the work “Intra-abdominal fat estimation combining the non-insulin-based METS-IR and Whtr indexes (METS-VAT)”
- https://www.endocrine.org/awards/presidential-poster-competition
Professional associations
Endocrine Society
In-training member
N/A
Current - 2019
Innovations
Mechanistic Score for COVID-19 lethality (MSL-COVID-19)
Clinical Estimator
N/A
2020
- We developed a mechanistic score to evaluate the risk for complications and lethality attributable to SARS-CoV2, considering the effect of obesity and diabetes in Mexico. Our score offers a clinical tool for quick determination of high-risk susceptibility patients in a first-contact scenario.
- doi:10.1371/journal.pone.0244051
Metabolic Score for Visceral Fat (METS-VF)
Clinical Estimator
N/A
2019
- Using as starting point the availability of body composition evaluations with intra-abdominal fat estimation by dual X-ray absorptiometry (DXA) obtained in the Metabolic Disease Research Unit at the INCMNSZ, I developed an equation that combines METS-IR with age, sex and waist-to-height ratio to estimate visceral adiposity, as well as metabolic risk for type 2 diabetes mellitus and incident systemic arterial hypertension. It is specific for Mexican and Latin American population.
- Published on: doi:10.1016/j.clnu.2019.07.012
Congress Presentations
Poster presentation
ENDO 2019
New Orleans, Louisiana.
2019
- The Non-insulin-based METS-IR Index Combined With Liver Transaminases Improves Prediction of Fatty Liver and Fibrosis.
- Bello-Chavolla OY, Vargas-Vazquez A, Almeda-Valdes P, Antonio- Villa NE, Aguilar Salinas CA.
Poster presentation
ENDO 2019
New Orleans, Louisiana.
2019
- Intra-abdominal Fat Estimation Combining The Non-insulin-based METS-IR And WHtr Indexes (METS-VF).
- Antonio-Villa NE, Bello-Chavolla OY.
Oral presentation.
ENDO 2019
New Orleans, Louisiana.
2019
- NMRI-metabolomics Variables Associated With The Metabolically-healthy Obese Phenotype And The Transitions Between Metabolically-healthy And Unhealthy Obesity Phenotypes.
- Vargas-Vázquez A, Bello-Chavolla OY, Antonio-Villa NE.
Scientific Publications
Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection
BMJ open diabetes research & care
N/A
2021
- Vargas-Vázquez, A., Bello-Chavolla, O. Y., Ortiz-Brizuela, E., Campos-Muñoz, A., Mehta, R., Villanueva-Reza, M., Bahena-López, J. P., Antonio-Villa, N. E., González-Lara, M. F., Ponce de León, A., Sifuentes-Osornio, J., & Aguilar-Salinas, C. A.
- https://doi.org/10.1136/bmjdrc-2020-002026
Adaptive metabolic and inflammatory responses identified using accelerated aging metrics are linked to adverse outcomes in severe SARS-CoV-2 infection.
The journals of gerontology. Series A, Biological sciences and medical sciences
N/A
2021
- Márquez-Salinas, A., Fermín-Martínez, C. A., Antonio-Villa, N. E., Vargas-Vázquez, A., C Guerra, E., Campos-Muñoz, A., Zavala-Romero, L., Mehta, R., Bahena-López, J. P., Ortiz-Brizuela, E., González-Lara, M. F., Roman-Montes, C. M., Martinez-Guerra, B. A., Ponce de Leon, A., Sifuentes-Osornio, J., Gutiérrez-Robledo, L. M., Aguilar-Salinas, C. A., & Bello-Chavolla, O. Y.
- https://doi.org/10.1093/gerona/glab078
Left ventricular and atrial global strain evaluation within subtypes of ventricular remodeling.
Echocardiography
N/A
2021
- Espinola-Zavaleta, N., Antonio-Villa, N. E., Briseño-Diaz, N., Oregel-Camacho, D., Camacho-Camacho, G., Keirns, C., & Alexanderson-Rosas, E.
- https://doi.org/10.1111/echo.14981
Familial hypercholesterolemia in Mexico: Initial insights from the national registry.
Journal Clinical Lipidology
N/A
2021
- Mehta R, Martagon AJ, Galan Ramirez GA, Antonio-Villa NE, Vargas-Vázquez A, Elias-Lopez D, et al.
- https://doi.org/10.1016/j.jacl.2020.12.001
Validation and repurposing of the MSL-COVID-19 score for prediction of severe COVID-19 using simple clinical predictors in a triage setting: The Nutri-CoV score.
PloS one
N/A
2021
- Bello-Chavolla, O. Y., Antonio-Villa, N. E., Ortiz-Brizuela, E., Vargas-Vázquez, A., González-Lara, M. F., de Leon, A. P., Sifuentes-Osornio, J., & Aguilar-Salinas, C. A.
- https://doi.org/10.1371/journal.pone.0244051
Increased visceral fat accumulation modifies the effect of insulin resistance on arterial stiffness and hypertension risk.
Nutrition, metabolism, and cardiovascular diseases
N/A
2020
- Antonio-Villa, N. E., Bello-Chavolla, O. Y., Vargas-Vázquez, A., Mehta, R., Fermín-Martínez, C. A., Martagón-Rosado, A. J., Barquera-Guevara, D. A., Aguilar-Salinas, C. A., & Metabolic Syndrome Study Group
- https://doi.org/10.1016/j.numecd.2020.09.031
Profiling cases with non-respiratory symptoms and asymptomatic SARS-CoV-2 infections in Mexico City.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
N/A
2020
- Bello-Chavolla, O. Y., Antonio-Villa, N. E., Vargas-Vázquez, A., Fermín-Martínez, C. A., Márquez-Salinas, A., & Bahena-López, J. P.
- https://doi.org/10.1093/cid/ciaa1288
Use of an electronic integral monitoring system for patients with diabetes to identify factors associated with an adequate glycemic goal and to measure quality of care.
Primary care diabetes
N/A
2020
- Antonio-Villa, N. E., Palma-Moreno, B. G., Rodríguez-Dávila, F. M., Gómez-Pérez, F. J., Aguilar-Salinas, C. A., Hernández-Jiménez, S., García-Ulloa, A. C., & Almeda-Valdes, P.
- https://doi.org/10.1016/j.pcd.2020.07.009
Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach.
BMJ open diabetes research & care
N/A
2020
- Bello-Chavolla, O. Y., Bahena-López, J. P., Vargas-Vázquez, A., Antonio-Villa, N. E., Márquez-Salinas, A., Fermín-Martínez, C. A., Rojas, R., Mehta, R., Cruz-Bautista, I., Hernández-Jiménez, S., García-Ulloa, A. C., Almeda-Valdes, P., Aguilar-Salinas, C. A., Metabolic Syndrome Study Group, & Group of Study CAIPaDi
- https://doi.org/10.1136/bmjdrc-2020-001550
Unequal impact of structural health determinants and comorbidity on COVID-19 severity and lethality in older Mexican adults: Considerations beyond chronological aging.
The journals of gerontology. Series A, Biological sciences and medical sciences
N/A
2020
- Bello-Chavolla, O. Y., González-Díaz, A., Antonio-Villa, N. E., Fermín-Martínez, C. A., Márquez-Salinas, A., Vargas-Vázquez, A., Bahena-López, J. P., García-Peña, C., Aguilar-Salinas, C. A., & Gutiérrez-Robledo, L. M.
- https://doi.org/10.1093/gerona/glaa163
Predicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexico
The Journal of Clinical Endocrinology and Metabolism
N/A
2020
- Bello-Chavolla, O. Y., Bahena-López, J. P., Antonio-Villa, N. E., Vargas-Vázquez, A., González-Díaz, A., Márquez-Salinas, A., Fermín-Martínez, C. A., Naveja, J. J., & Aguilar-Salinas, C. A. (2020).
- https://doi.org/10.1210/clinem/dgaa346
Optimal Medical Treatment vs. Invasive Approach in Patients with Significantly Obstructive Coronary Artery Disease and Ischemia.
Archives of Medical Research
N/A
2020
- Carvajal-Juarez, I., Espínola-Zavaleta, N., Antonio-Villa, N. E., Keirns, C., & Alexanderson-Rosas, E.
- https://doi.org/10.1016/j.arcmed.2020.04.002
The combination of insulin resistance and visceral adipose tissue estimation improves the performance of metabolic syndrome as a predictor of type 2 diabetes.
Diabetic Medicine : A Journal of the British Diabetic Association
N/A
2020
- Antonio-Villa, N. E., Bello-Chavolla, O. Y., Vargas-Vázquez, A., Mehta, R., Aguilar-Salinas, C. A., & Metabolic Syndrome Study Group
- https://doi.org/10.1111/dme.14274
Metabolic Score for Visceral Fat (METS-VF), a novel estimator of intra-abdominal fat content and cardio-metabolic health.
Clinical Nutrition
N/A
2019
- Bello-Chavolla OY, Antonio-Villa NE, Vargas-Vázquez A, Viveros-Ruiz T, Almeda-Valdes P, Gomez-Velasco D, Mehta R, Elias-López D, Cruz-Bautista I, Roldán-Valadez E, Martagón AJ, Aguilar-Salinas CA.
- https://doi.org/10.1016/j.clnu.2019.07.012
Prediction of incident hypertension and arterial stiffness using the non-insulin based METS-IR index.
Journal of clinical hypertension
N/A
2019
- Bello-Chavolla OY and Antonio-Villa NE, Vargas-Vázquez A, Martagón AJ, Mehta R, Arellano-Campos O, Gómez-Velasco DV, Cruz-Bautista I, Melgarejo-Hernandez MA, Muñoz-Hernandez L, Guillén LE, Garduño-García JJ, Alvirde U, Ono-Yoshikawa Y, Choza-Romero R, Sauque-Reyna L, Garay-Sevilla ME, Malacara-Hernandez JM, Tusié-Luna MT, Gutierrez-Robledo LM, Gómez-Pérez FJ, Rojas R, Aguilar-Salinas, CA.
- https://doi.org/10.1111/jch.13614
Diastolic dyssynchrony assessment by gated myocardial perfusion-SPECT in subjects who underwent cardiac resynchronization therapy
Journal of Nuclear Cardiololgy
N/A
2019
- Alexanderson-Rosas E, Espinola-Zavaleta N, Garcia EV, Peix A, Massardo T, Pabon LM, Antonio-Villa NE, Carvajal-Juarez I, Mesquita CT, Jimenez-Heffernan A, Patel C, Karthikeyan G, Kumar A, Butt S, Kalaivani M, Marin V, Morozova O, Paez D.
- https://doi.org/10.1007/s12350-019-01845-2
Comorbid conditions in individuals assessed by SPECT: Study of a reference cardiology center in Mexico City.
Journal of Nuclear Cardiololgy
N/A
2019
- Antonio-Villa NE, Espínola-Zavaleta N, Carvajal-Juárez I, Flores-Garcia AN, Alexanderson-Rosas E.
- https://doi.org/10.1007/s12350-019-01737-5
Pathophysiological mechanisms linking type 2 diabetes and dementia: Review of evidence from clinical, translational and epidemiological research.
Current Diabetes Reviews
N/A
2019
- Bello-Chavolla OY, Antonio-Villa NE, Vargas-Vázquez A, Ávila-Funes JA, Aguilar-Salinas CA.
- https://doi.org/10.2174/1573399815666190129155654